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The patient should be monitored closely to avoid undertreatment or overtreatmentUndertreatment may have deleterious effects on intellectual development and linear growthOvertreatment has been associated with craniosynostosis in infantsand may adversely affect the tempo of brain maturation and accelerate the bone age with resultant premature closure of the epiphyses and compromised adult stature.

The target level for TSH suppression in these conditions has not been established with controlled studiesIn additionthe efficacy of TSH suppression for benign nodular disease is controversialThereforethe dose of SYNTHROID used for TSH suppression should be individualized based on the specific disease and the patient being treated.

Cardiac function was evaluated in twenty patients requiring TSH suppression for either thyroid goiter or following thyroidectomy and radioactive iodine therapy for thyroid cancer and in twenty ageand sex-matched controlsTSH suppression was associated with an increased incidence of premature ventricular beatsan increased left ventricular mass indexand enhanced left ventricular systolic functionThe clinical significance of these changes remains to be determinedRef]

Levothyroxine is also effective in the suppression of pituitary TSH secretion in the treatment or prevention of various types of euthyroid goitersincluding thyroid nodulesHashimoto’s thyroiditismultinodular goiter andas adjunctive therapy in the management of thyrotropin-dependent welldifferentiated thyroid cancersee INDICATIONS AND USAGEPRECAUTIONSand DOSAGE AND ADMINISTRATION

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my advice would be to get a paper rx and send it off to canada where you will get the same synthroid as sold in u.

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