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Do not use any other over-the-counter coldallergyor pain medication without first asking your doctor or pharmacistMany medicines available over the counter contain medicines similar to mefenamic acidsuch as aspirinibuprofenketoprofenor naproxenIf you take certain products together you may accidentally take too much of this type of medicationRead the label of any other medicine you are using to see if it contains aspirinibuprofenketoprofenor naproxen.

NSAIDs cause an increased risk of serious gastrointestinalGIadverse events including bleedingulcerationand perforation of the stomach or intestineswhich can be fatalThese events can occur at any time during use and without warning symptomsElderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI eventssee WARNINGS

Dosage is based on your medical condition and response to therapyTo reduce your risk of stomach bleeding and other side effectstake this medication at the lowest effective dose for the shortest possible timeDo not increase your dosetake it more frequentlyor take it for a longer time than prescribedThis medication usually should not be taken for more than 7 days at a time.

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusionIn these patientsadministration of an NSAID may cause a dose-dependent reduction in prostaglandin formation andsecondarilyin renal blood flowwhich may precipitate overt renal decompensationPatients at greatest risk of this reaction are those with impaired renal functiondehydrationhypovolemiaheart failureliver dysfunctionthose taking diuretics and ACE inhibitors or ARBsand the elderlyDiscontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.

Stop taking mefenamic acid and seek medical attention or call your doctor at once if you have any of these serious side effects:

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common side effects associated with ponstel use may include constipation, diarrhea, dizziness, gas, headache, heartburn, nausea, and stomach upset.

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