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Avoid administration of PPIs for longer than medically indicatedIf signs or symptoms consistent with CLE or SLE are noted in patients receiving NEXIUMdiscontinue the drug and refer the patient to the appropriate specialist for evaluationMost patients improve with discontinuation of the PPI alone in 4 to 12 weeks.

New or worsening symptoms of lupusjoint painand a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone in your hipwristor spine while taking a proton pump inhibitor long-term or more than once per dayTalk with your doctor about ways to keep your bones healthy.

Taking esomeprazole long-term may cause you to develop stomach growths called fundic gland polypsTalk with your doctor about this risk.

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