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Patients with rare hereditary problems of galactose intolerancethe Lapp-lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Rizatriptan should be used with caution in dialysis patients due to a decrease in the clearance of rizatriptan.

Rizatriptanshould not be given to patients with ischemic or vasospastic coronary artery diseaseThere have been rare reports of serious cardiac adverse reactionsincluding acute myocardial infarctionoccurring within a few hours following administration of rizatriptanSome of these reactions occurred in patients without known coronary artery diseaseCAD5-HT1 agonistsincluding rizatriptanmay cause coronary artery vasospasmPrinzmetal’s Anginaeven in patients without a history of CAD.

Chemical propertiesrizatriptan may bind to melanin and accumulate in melanin-rich tissuee.geyesover timeThis raises the possibility that rizatriptan could cause toxicity in these tissues after extended useThere werehoweverno adverse ophthalmologic changes related to treatment with rizatriptan in the 1-year dog toxicity studyAlthough no systematic monitoring of ophthalmologic function was undertaken in clinical trials and no specific recommendations for ophthalmologic monitoring are offeredprescribers should be aware of the possibility of long-term ophthalmologic effects.

The administration of rizatriptan with other 5-HT 1 agonistse.gsumatriptanzolmitriptannaratriptanhas not been evaluated in migraine patientsBecause their vasospastic effects may be additiveco-administration of rizatriptanand other 5-HT 1 agonists within 24 hours of each other is not recommended.

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